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Safe and effective fertilizer application requires following product labels, calibrating equipment, and using best practices. Always read and follow the instructions on the fertilizer label for proper application rates and methods. Calibrate spreaders or sprayers to ensure even distribution. Apply fertilizers when plants are actively growing and avoid applying before heavy rains to prevent runoff. Water in granular fertilizers after application. Consider using slow-release or controlled-release formulations to provide a steady nutrient supply. Refer to resources from the Oregon State University Extension for more fertilizer safety and effectiveness tips.