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While lime is generally safe when used as directed, there are some precautions to keep in mind. Lime can irritate eyes, skin, and respiratory passages, so wear protective gear like goggles and a mask when handling and applying it. Avoid inhaling lime dust. Keep lime away from pets and children, as ingesting large amounts can be harmful. According to Penn State Extension, never combine lime and fertilizer together, as this causes nitrogen loss. Be careful not to over-lime your soil, as raising pH too high can create new nutrient deficiencies. Always follow product label instructions and take care when spreading lime evenly.